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The Cytoplasmic Domain of Glycoprotein (GP) Ibα Constrains the Lateral Diffusion of the GP Ib−IX Complex and Modulates von Willebrand Factor Binding †

✍ Scribed by Dong, Jing-Fei; Li, Chester Q.; Sae-Tung, Garunee; Hyun, William; Afshar-Kharghan, Vahid; López, José A.

Book ID: 126277443
Publisher: American Chemical Society
Year: 1997
Tongue: English
Weight: 171 KB
Volume: 36
Category: Article
ISSN: 0006-2960
DOI: 10.1021/bi970636b

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## Background and objective: Thrombus formation is initiated by adhesion of the platelet receptor, glycoprotein (gp) ib-ix-v complex, to its adhesive ligand, von willebrand factor (vwf), in the subendothelium or plasma. the vwf-binding domain of gp ib-ix-v is in the gp ibalpha subunit of the comple