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Purified A2 domain of von Willebrand factor binds to the active conformation of von Willebrand factor and blocks the interaction with platelet glycoprotein Ibα

✍ Scribed by C. MARTIN; L. D. MORALES; M. A. CRUZ


Book ID
109152111
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
689 KB
Volume
5
Category
Article
ISSN
1538-7933

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## Background and objective: Thrombus formation is initiated by adhesion of the platelet receptor, glycoprotein (gp) ib-ix-v complex, to its adhesive ligand, von willebrand factor (vwf), in the subendothelium or plasma. the vwf-binding domain of gp ib-ix-v is in the gp ibalpha subunit of the comple