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The Cystatin-C gene is not linked to early onset familial Alzheimer's disease

✍ Scribed by Parfitt, Matthew; Crook, Richard; Roques, Penelope; Rossor, Martin; Chartier-Harlin, Marie-Christine


Book ID
122099018
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
307 KB
Volume
154
Category
Article
ISSN
0304-3940

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Early onset familial Alzheimer's disease (AD) has an autosomal dominant mode of inheritance. T w o genes are responsible for the majority of cases of this subtype of AD. Mutations in the P-amyloid precursor protein (PAPP) gene on chromosome 21 have been shown to completely cosegregate with the disea