Cyclosporin A (CsA) inhibits the in vitro replication of HCV subgenomic replicons. We here report on the potent anti-HCV activity of the non-immunosuppressive cyclosporin DEBIO-025. The 50% effective concentration for inhibition of HCV subgenomic replicon replication in Huh 5-2 cells (luciferase ass
The Cyclophilin Inhibitor Debio-025 is a Potent Inhibitor of Hepatitis C Virus Replication in vitro With a Unique Resistance Profile
✍ Scribed by Lotte Coelmont; Jan Paeshuyse; Suzanne Kaptein; Inge Vliegen; Artur Kaul; Erik De Clercq; Brigitte Rosenwirth; Pietro Scalfaro; Raf Crabbé; Ralf Bartenschlager; Jean-Maurice Dumont; Johan Neyts
- Book ID
- 113457448
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 64 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0166-3542
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Debio-025 is an oral cyclophilin (Cyp) inhibitor with potent anti-hepatitis C virus activity in vitro. Its effect on viral load as well as its influence on intracellular Cyp levels was investigated in a randomized, double-blind, placebo-controlled study. Mean hepatitis C viral load decreased signifi
The anti-hepatitis C virus (HCV) effect and safety of three different oral doses of the cyclophilin inhibitor Debio 025 in combination with pegylated interferon-␣2a (PEG IFN-␣2a) were investigated in a multicenter, randomized, double-blind, placebo-controlled escalating dose-ranging phase II study i