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In vitro Anti-hepatitis C Virus (HCV) Activities and Resistance Profile of Debio 025, A Non-immunosuppressive Cyclophilin Binding Molecule

✍ Scribed by Lotte Coelmont; Philippe Gallay; Michael Bobardt; Suzanne Kaptein; Jan Paeshuyse; Inge Vliegen; Grégoire Vuagniaux; Johan Neyts

Book ID: 113457921
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 76 KB
Volume: 82
Category: Article
ISSN: 0166-3542
DOI: 10.1016/j.antiviral.2009.02.024

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Cyclosporin A (CsA) inhibits the in vitro replication of HCV subgenomic replicons. We here report on the potent anti-HCV activity of the non-immunosuppressive cyclosporin DEBIO-025. The 50% effective concentration for inhibition of HCV subgenomic replicon replication in Huh 5-2 cells (luciferase ass