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The Current Status of Metabolomics in Drug Discovery and Development

✍ Scribed by Robertson, Donald G.; Reily, Michael D.

Book ID
118757873
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
186 KB
Volume
73
Category
Article
ISSN
0272-4391

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## Abstract Metabolism by the host organism is one of the most important determinants of the pharmacokinetic profile of a drug. High metabolic lability usually leads to poor bioavailability and high clearance. Formation of active or toxic metabolites will have an impact on the pharmacological and t