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The current evidence for defective repair of oxidatively damaged DNA in Cockayne syndrome

✍ Scribed by Guido Frosina

Book ID: 113630313
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 525 KB
Volume: 43
Category: Article
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2007.04.001

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## Abstract Oxidative damage represents the most significant insult to organisms because of continuous production of the reactive oxygen species (ROS) in vivo. Oxidative damage in DNA, a critical target of ROS, is repaired primarily via the base excision repair (BER) pathway which appears to be the