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The cumulative occurrence of resistance mutations in the HIV-1 protease gene is associated with failure of salvage therapy with ritonavir and saquinavir in protease inhibitor-experienced patients

✍ Scribed by Marina Karmochkine; Ali Si Mohamed; Christophe Piketty; Christine Ginsburg; Gilles Raguin; Véronique Schneider-Fauveau; Laurent Gutmann; Michel D. Kazatchkine; Laurent Belec


Book ID
114144103
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
120 KB
Volume
47
Category
Article
ISSN
0166-3542

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## Abstract This study aimed at identifying HIV‐1 protease amino acid changes associated with protease inhibitor (PI) exposure and susceptibility. New amino acid substitutions were correlated with the number of experienced PIs, reaching statistical significance only for those at positions 3, 44, an