Drug resistance mutations and newly recognized treatment-related substitutions in the HIV-1 protease gene: Prevalence and associations with drug exposure and real or virtual phenotypic resistance to protease inhibitors in two clinical cohorts of antiretroviral experienced patients
✍ Scribed by Carlo Torti; Eugenia Quiros-Roldan; Laura Monno; Andrea Patroni; Annalisa Saracino; Gioacchino Angarano; Carmine Tinelli; Sergio Lo Caputo; Valeria Tirelli; Francesco Mazzotta; Giampiero Carosi
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 123 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0146-6615
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
This study aimed at identifying HIV‐1 protease amino acid changes associated with protease inhibitor (PI) exposure and susceptibility. New amino acid substitutions were correlated with the number of experienced PIs, reaching statistical significance only for those at positions 3, 44, and 74. The correspondence multivariate model demonstrated that ≥3 experienced PIs and substitutions or mutations at positions 3, 46, 54, 73, 74, and 84 were correlated with PI cross‐resistance, including resistance for lopinavir and amprenavir in this cohort of patients who were naive for these drugs. J. Med. Virol. 74:29–33, 2004. © 2004 Wiley‐Liss, Inc.