Structure of a mutant human purine nucle
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Sepideh Afshar; Michael R. Sawaya; Sherie L. Morrison
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Article
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2009
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Cold Spring Harbor Laboratory Press
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English
β 622 KB
## Abstract A double mutant of human purine nucleoside phosphorylase (hDM) with the amino acid mutations Glu201Gln:Asn243Asp cleaves adenosineβbased prodrugs to their corresponding cytotoxic drugs. When fused to an antiβtumor targeting component, hDM is targeted to tumor cells, where it effectively