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The Cryopreservation of Leukaemia Cells: Morphological and Functional Changes

✍ Scribed by R. M. Lowenthal; Diana S. Park; J. M. Goldman; K. H. Th'ng; R. S. Hill; G. Whyte

Book ID
114708363
Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
904 KB
Volume
34
Category
Article
ISSN
0007-1048

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Cyclosporin A (50 mg/kg orally for 7 days) produced severe degranulation and hydropic degeneration of islet B cells in rats. These changes were accompanied by hyperglycaemia and hypoinsulinaemia, while the pancreatic insulin content decreased by 75%.