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The Crocacins, Novel Antifungal and Cytotoxic Antibiotics from Chondromyces crocatus and Chondromyces pediculatus (Myxobacteria): Isolation and Structure Elucidation

✍ Scribed by Rolf Jansen; Peter Washausen; Brigitte Kunze; Hans Reichenbach; Gerhard Höfle

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
270 KB
Volume
1999
Category
Article
ISSN
1434-193X

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✦ Synopsis

Four novel antifungal and highly cytotoxic metabolites, the polyketide-derived acyl residue. The latter is a multiply substituted phenylundecatrienoic acid, which is found as its crocacins A-D (1-4), were isolated in our screening of the myxobacterial genus Chondromyces from strains of C. primary amide crocacin C (3). Based on 1 H coupling constants, NOEs and MM + calculations the relative crocatus and C. pediculatus. Crocacin A, B, and D (1, 2, and 4) are unusual dipeptides of glycine and a 6-aminohexenoic configuration of the asymmetric centers and their preferred conformation are proposed for the crocacins. or -hexadienoic acid, which is N-protected by a complex

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✍ Rolf Jansen; Brigitte Kunze; Hans Reichenbach; Gerhard Höfle 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 303 KB 👁 2 views

A novel highly cytotoxic metabolite, apicularen A (1), was isolated in a screening of the myxobacterial genus Chondromyces. The structure of 1 is characterized by a salicylic acid residue as part of a 10-membered lactone, which bears an acylenamine side chain. Compound 1 is an inhibitor of the proli