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ChemInform Abstract: Antibiotics from Gliding Bacteria. Part 86. Apicularen A (Ia) and B (Ib), Cytotoxic 10-Membered Lactones with a Novel Mechanism of Action from Chondromyces Species (Myxobacteria). Isolation, Structure Elucidation, and Biosynthesis.

✍ Scribed by Rolf Jansen; Brigitte Kunze; Hans Reichenbach; Gerhard Hoefle


Publisher
John Wiley and Sons
Year
2010
Weight
27 KB
Volume
31
Category
Article
ISSN
0931-7597

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Apicularen A and B, Cytotoxic 10-Membere
✍ Rolf Jansen; Brigitte Kunze; Hans Reichenbach; Gerhard HΓΆfle πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 303 KB πŸ‘ 2 views

A novel highly cytotoxic metabolite, apicularen A (1), was isolated in a screening of the myxobacterial genus Chondromyces. The structure of 1 is characterized by a salicylic acid residue as part of a 10-membered lactone, which bears an acylenamine side chain. Compound 1 is an inhibitor of the proli