Apicularen A and B, Cytotoxic 10-Membere
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Rolf Jansen; Brigitte Kunze; Hans Reichenbach; Gerhard HΓΆfle
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Article
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2000
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John Wiley and Sons
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English
β 303 KB
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A novel highly cytotoxic metabolite, apicularen A (1), was isolated in a screening of the myxobacterial genus Chondromyces. The structure of 1 is characterized by a salicylic acid residue as part of a 10-membered lactone, which bears an acylenamine side chain. Compound 1 is an inhibitor of the proli