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The critical role of CD28 signalling in the prevention of human T-cell anergy

โœ Scribed by V.A. Boussiotis; G.J. Freeman; J.G. Gribben; L.M. Nadler


Book ID
116158150
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
974 KB
Volume
146
Category
Article
ISSN
0923-2494

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## Abstract Although signal pathways triggered __via__ the CD40 molecule are well characterized, those induced __via__ CD154 are less known. This study demonstrates that engagement of CD154 in Jurkat D1.1 cells with soluble CD40 leads to PKC ฮฑ and ฮด activation, calcium mobilization, and phosphoryla