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The Cotranslational Integration of Membrane Proteins into the Phospholipid Bilayer Is a Multistep Process

โœ Scribed by Hung Do; Domina Falcone; Jialing Lin; David W Andrews; Arthur E Johnson

Book ID
117268003
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
287 KB
Volume
85
Category
Article
ISSN
0092-8674

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The four transmembrane domain topology of the proteolipid protein (PLP) in the myelin membrane of the central nervous system (CNS) has been further substantiated by biochemical studies. We have analyzed the cotranslational polytopic integration of nascent PLP during protein synthesis into the membra