The correlation between MGMT gene methylation, MGMT protein expression and p53 mutation in glioblastoma
β Scribed by Lotfi Marzieh; Sharif Samaneh; Afsharnezhad Sima; Raziee Hamid Reza; Behravan Javad; Moradi Afshin
- Book ID
- 118431193
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 50 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0009-9120
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π SIMILAR VOLUMES
Repair of cytotoxic DNA damage by O 6 -methylguanine-DNA methyltransferase (MGMT) is a potentially important factor of chemoresistance to chloroethylnitrosoureas (CE-NUs), commonly used in the treatment of glioblastoma multiforme (GBM). The value of p53 as a prognostic factor in GBMs remains unclear
A discordance between p53 protein overexpression and the presence of mutations in the gene has been observed in many types of tumors, including human lymphomas. To probe this finding, we have studied a large series of 94 lymphomas of different pathologic types and histologic differentiation. Analyzi