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MGMT promoter methylation and correlation with protein expression in primary central nervous system lymphoma

โœ Scribed by Toffolatti, L.; Scquizzato, E.; Cavallin, S.; Canal, F.; Scarpa, M.; Stefani, P. M.; Gherlinzoni, F.; Dei Tos, A. P.


Book ID
125815586
Publisher
Springer
Year
2014
Tongue
English
Weight
880 KB
Volume
465
Category
Article
ISSN
1432-2307

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The enzyme O 6 -methylguanine-DNA methyltransferase (MGMT) protects cells from the cytotoxic and mutagenic effects of alkylating agents. Approximately 20% of tumor cell lines lack MGMT activity and are highly sensitive to alkylating agents. In established cancer cell lines, MGMT expression appears t