The objective of this study is to evaluate the predictive performance of the rule of exponents (ROE) and 'fu Corrected Intercept Method' (FCIM) for the human drug clearance. Different classes of drugs such as extensively metabolized, renally excreted, renally secreted, and biliary excreted drugs wer
The correction factors do help in improving the prediction of human clearance from animal data
β Scribed by Iftekhar Mahmood
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 74 KB
- Volume
- 94
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
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Values for V,, and K, determined during the in vitro metabolism of a xenobiotic to a known metabolite by a specific human isozyme of cytochrome P450 (P450) were used to predict the hepatic clearance (CLH) of the xenobiotic to that metabolite. The calculated CLH values were then compared to literatur
This study was conducted to comprehensively evaluate the performance of various allometric scaling methods for the prediction of human clearance. Allometric scaling was used to predict clearance for 103 compounds, for which clearance data in the rat, dog, monkey, and humans were available. Allometry
In Table 3, the MAE value for three-species allometric scaling using the rule of exponents should be 6.44, not 11.03 as originally cited. This error resulted from an incorrect predicted value for one of the 103 compounds in the dataset (nicotine; incorrect error of 479.6 mL/min/kg rather than the co