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The Conventional Transforming Growth Factor-β (TGF-β) Receptor Type I Is Not Required for TGF-β1 Signaling in a Human Prostate Cancer Cell Line, LNCaP

✍ Scribed by Isaac Yi Kim; David J. Zelner; Chung Lee


Book ID
115602951
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
557 KB
Volume
241
Category
Article
ISSN
0014-4827

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Transforming growth factor-b (TGF-b1) is a potent negative regulator of cell growth that transduces signals through interactions with type I and II receptors. Abnormal expression and mutational alterations of these receptors have been observed in several human malignancies. In this study, we investi