𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The contributory role of interstitial water in Gd-DTPA-enhanced MRI in myocardial infarction

✍ Scribed by Shin-ichi Inoue; Yo Murakami; Koichi Ochiai; Jun Kitamura; Yutaka Ishibashi; Hideaki Kawamitsu; Kazuro Sugimura; Toshio Shimada

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
191 KB
Volume
9
Category
Article
ISSN
1053-1807

No coin nor oath required. For personal study only.

✦ Synopsis

We studied the mechanism underlying regional enhancement of myocardial infarction using T1-weighted MRI with gadolinium (Gd)-DTPA. Anterior myocardial infarction (MI) was produced by left anterior descending coronary artery ligation in three groups of rats as follows: 60 minutes occlusion (occlusion group, N ‫؍‬ 6), 60 minutes occlusion plus 120 minutes reperfusion (reperfusion group, N ‫؍‬ 8), and sham-operated (control, N ‫؍‬ 6). In Gd-DTPA-enhanced MRI, MI was demarcated as a hypoenhanced region in the occlusion group and as a homogeneous hyperenhanced region in the reperfusion group. Both Gd-DTPA tissue concentration and tissue water content in the anterior wall were highest in the reperfusion group (P F 0.05), a finding suggestive of microscopically observed interstitial edema. The data suggest that regional accumulation of Gd-DTPA in the reperfused group can be explained by increased interstitial water content, contributing to the delayed washout of the water-soluble contrast medium.

📜 SIMILAR VOLUMES

Does binding of Gd-DTPA to myocardial ti
Does binding of Gd-DTPA to myocardial tissue contribute to late enhancement in a model of acute myocardial infarction?
✍ Ulrich K.M. Decking; Vinay M. Pai; Han Wen; Robert S. Balaban 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 79 KB

## Abstract The long‐lasting signal enhancement by Gd‐DTPA in areas of myocardial infarction has been conventionally explained by low perfusion and an enhanced Gd distribution volume. To test whether binding of Gd to myocardial constituents is an additional factor contributing to this effect, Gd‐DT

Dynamic contrast-enhanced MRI using Gd-D
Dynamic contrast-enhanced MRI using Gd-DTPA: Interindividual variability of the arterial input function and consequences for the assessment of kinetics in tumors
✍ Ruediger E. Port; Michael V. Knopp; Gunnar Brix 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 244 KB 👁 1 views

Gd-DTPA kinetics in arterial blood was investigated by dynamic MRI in 47 patients with malignant and benign mammary tumors. Signal enhancement was monitored for 10 min after the beginning of a 1-min infusion of 0.1 mmol/kg Gd-DTPA. Kinetics in blood was biexponential with median half-lives of 21 sec

Feasibility of the single-bolus strategy
Feasibility of the single-bolus strategy for measuring the partition coefficient of Gd-DTPA in patients with myocardial infarction: Independence of image delay time and maturity of scar
✍ Rebecca E. Thornhill; Frank S. Prato; Gerald Wisenberg; James A. White; Judith N 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 460 KB

## Abstract The partition coefficient of Gd‐DTPA (λ) is elevated in infarcted relative to normal myocardium. Although MRI following an infusion of Gd‐DTPA allows for the quantification of λ, infarct imaging is more routinely performed using a bolus. In this study we sought to determine how image de

Cellular-interstitial water exchange and
Cellular-interstitial water exchange and its effect on the determination of contrast agent concentration in vivo: Dynamic contrast-enhanced MRI of human internal obturator muscle
✍ David L. Buckley; Lucy E. Kershaw; Greg J. Stanisz 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 404 KB

## Abstract The purpose of this study was to assess the effects of cellular‐interstitial water exchange on estimates of tracer kinetics parameters obtained using rapid dynamic contrast‐enhanced (DCE) MRI. Data from the internal obturator muscle of six patients were examined using three models of wa