Feasibility of the single-bolus strategy for measuring the partition coefficient of Gd-DTPA in patients with myocardial infarction: Independence of image delay time and maturity of scar
✍ Scribed by Rebecca E. Thornhill; Frank S. Prato; Gerald Wisenberg; James A. White; Judith Nowell; Anya Sauer
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 460 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
The partition coefficient of Gd‐DTPA (λ) is elevated in infarcted relative to normal myocardium. Although MRI following an infusion of Gd‐DTPA allows for the quantification of λ, infarct imaging is more routinely performed using a bolus. In this study we sought to determine how image delay time and time postinfarction influence the estimation of λ by the bolus strategy. Both infusion and bolus imaging were performed twice in the same group of patients (N = 9): once at 3–4 weeks and again 6 months after reperfusion therapy for myocardial infarction (MI). Bolus estimates of λ were compared with those calculated after 60 min infusion, and comparisons were repeated at 6 months. The λ of infarcted myocardium was significantly greater than that of normal tissue, irrespective of either the technique used or the time postinfarction (P < 0.0001, for each). The concordance (R~c~) between bolus and infusion estimates of λ was >0.83 for all image delays >4 min postinjection, and R~c~ at 2 min (0.78 ± 0.04) was significantly less than R~c~ determined for longer image delay times (P = 0.009). R~c~ did not change with time postinfarction (P = 0.604). Thus, the bolus strategy can be used to provide estimates of λ that are stable from 1–6 months postinfarction and independent of image delay time. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.