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The configuration of the substituents at the nitrogen atom of tropine ethobromide

โœ Scribed by P. Benci; C.H. Stam; C.H. MacGillavry

Publisher
Elsevier Science
Year
1971
Tongue
French
Weight
113 KB
Volume
12
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Fodor (1) has formulated a rule stating that when two different groups are attached Successively to the nitrogen atom of nortropane derivatives, the group entering last is fixed in the equatorial position with respect to the piperidine ring.

According to this rule N-ethylnortropine methobromide ( NEXTMB), which is obtained by quaternisation of N-ethyltropine with methylbromide, should have the methyl group in an equatorial poai-

๐Ÿ“œ SIMILAR VOLUMES

Absolute configuration of the substituen
Absolute configuration of the substituent at C-7 in guaiol
โœ Hitoshi Minato ๐Ÿ“‚ Article ๐Ÿ“… 1961 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 214 KB

Osaka, Japan IN the preceding papers,' it was eetabliehed that both the C-4 and the C-10 methyl Bronps in guaiol (I) poeseas the a-configuration. Now the question remains as to whether the eubetituent at C-7 in guaiol is aor $-oriented. In thin rxperiment, an attempt was made to determine the absolu