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The configuration of the Cu2+ binding region in full-length human prion protein compared with the isolated octapeptide

✍ Scribed by Andreas Weiss; Pablo del Pino; Uwe Bertsch; Christian Renner; Matthias Mentler; Klaus Grantner; Luis Moroder; Hans A. Kretzschmar; Fritz G. Parak


Book ID
113943242
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
756 KB
Volume
123
Category
Article
ISSN
0378-1135

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Structural characterization of a neuroto
✍ Luisa Ronga; Pasquale Palladino; Gabriella Saviano; Teodorico Tancredi; Ettore B πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 192 KB

## Abstract The 173–195 segment corresponding to the helix 2 of the globular PrP domain is a good candidate to be one of the several β€˜spots’ of intrinsic structural flexibility, which might induce local destabilization and concur to protein transformation, leading to aggregation‐prone conformations