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The concentration of 5-phosphoribosyl 1-pyrophosphate in monolayer tumor cells and the effect of various pyrimidine antimetabolites

โœ Scribed by G.J. Peters; E. Laurensse; A. Leyva; H.M. Pinedo


Book ID
107770510
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
486 KB
Volume
17
Category
Article
ISSN
0020-711X

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โœ S.Randolph May; Robert S. Krooth ๐Ÿ“‚ Article ๐Ÿ“… 1976 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 833 KB

The properties of an assay for the 5-phosphoribosyl-1-pyrophosphate (PRPP) content of cultured mammalian fibroblasts are described. The assay is based upon the PRPP-dependent release of "CO, from [carboxy/-"Clorotic acid by a commercially available preparation of yeast orotidine-5'-monophosphate pyr