✦ LIBER ✦

The concentration-effect relationship in the depolarization of amphibian nerve by potassium and other agents

✍ Scribed by Feng, T. P. ;Liu, Y. M.

Publisher: Wiley (John Wiley & Sons)
Year: 1949
Tongue: English
Weight: 519 KB
Volume: 34
Category: Article
ISSN: 0095-9898
DOI: 10.1002/jcp.1030340104

No coin nor oath required. For personal study only.

✦ Synopsis

THREE FIGURES

I n general any depolarizing agent depolarizes the nerve more at greater concentrations. But potassium appears to be the only agent for which attempts have been made to determine the quantitative relation between the degree of depolarization produced and the eoncentration of solution used. Curtis and Cole ('42) measured the resting potential of the squid giant axon as a function of the potassium ion concentration of its surrounding fluid. They found that in the physiological range of concentrations, i.e., from 0.1 to about 5 times that of sea water, there was only a small eliange of potential with concentration, but a t liiglier concentrations the

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