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The complete 1H and 13C chemical shift assignments of a cyclopropylpyrroloindole analog: Adozelesin

✍ Scribed by G. S. Walker; P. E. Fagemess; K. A. Farley; S. A. Mizsak

Publisher
Journal of Heterocyclic Chemistry
Year
1997
Tongue
English
Weight
328 KB
Volume
34
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

The ^1^H and ^13^C nmr spectral assignments of [7bR]‐N‐[2‐[(4,5,8,8a‐tetrahydro‐7‐methyl‐4‐oxocyclo‐propa[c]pyrrolo[3,2‐e]indol‐2(1__H__)‐ylcarbonyl]‐1__H__‐indol‐5‐yl]‐2‐benzofurancarboxamide (Adozelesin) (1) are described. Complete and unambiguous assignments of the hydrogen and carbon spectra were made using a combination of conventional homonuclear and gradient‐selected inverse‐detected heteronuclear nmr experiments: double quantum filtered ^1^H‐^1^H correlation spectroscopy (COSY), gradient‐selected heteronuclear single quantum coherence spectroscopy (gs‐HSQC), and gradient‐selected heteronuclear multiple bond coherence spectroscopy (gs‐HMBC). The enhanced sensitivity of these experiments allowed a smaller sample concentration and shorter spectral collection times for a full nmr analysis of this compound. The nmr data corroborates the published structure of this compound.

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