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The Complement Inhibitor Eculizumab in Paroxysmal Nocturnal Hemoglobinuria

✍ Scribed by Hillmen, Peter; Young, Neal S.; Schubert, Jörg; Brodsky, Robert A.; Socié, Gerard; Muus, Petra; Röth, Alexander; Szer, Jeffrey; Elebute, Modupe O.; Nakamura, Ryotaro; Browne, Paul; Risitano, Antonio M.; Hill, Anita; Schrezenmeier, Hubert; Fu, Chieh-Lin; Maciejewski, Jaroslaw; Rollins, Scott A.; Mojcik, Christopher F.; Rother, Russell P.; Luzzatto, Lucio


Book ID
126312505
Publisher
Massachusetts Medical Society
Year
2006
Tongue
English
Weight
271 KB
Volume
355
Category
Article
ISSN
0096-6762

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## Abstract Paroxysmal nocturnal hemoglobinuria (PNH) is a debilitating and life‐threatening disease in which lysis of PNH red blood cells frequently manifests with chronic hemolysis, anemia, and thrombosis. Renal damage in PNH is associated with chronic hemosiderosis and/or microvascular thrombosi