Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria
β Scribed by Rother, Russell P; Rollins, Scott A; Mojcik, Christopher F; Brodsky, Robert A; Bell, Leonard
- Book ID
- 109910984
- Publisher
- Nature Publishing Group
- Year
- 2007
- Tongue
- English
- Weight
- 680 KB
- Volume
- 25
- Category
- Article
- ISSN
- 1087-0156
- DOI
- 10.1038/nbt1344
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## Abstract Paroxysmal nocturnal hemoglobinuria (PNH) is a debilitating and lifeβthreatening disease in which lysis of PNH red blood cells frequently manifests with chronic hemolysis, anemia, and thrombosis. Renal damage in PNH is associated with chronic hemosiderosis and/or microvascular thrombosi
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