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The combined effects of high-energy shock waves and ionising radiation on a human bladder cancer cell line

✍ Scribed by Sonja Fickweiler; Pia Steinbach; Klaus Wörle; Ferdinand Hofstädter

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
750 KB
Volume
22
Category
Article
ISSN
0301-5629

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✦ Synopsis

The effects of high-energy shock waves (HESW) generated by an experimental Siemens lithotripter in combination with '"Cs y-rays were examined in vitro. Proliferation after treatment of immobilised pellets of either single cells or multicellular spheroids of the bladder cancer cell line RT4 was determined using colony-forming assays and cell cycle analysis. Surviving and cell cycle fractions were calculated for each shock wave and radiation application mode separately, and for sequential combination in different successions for the purpose of characterizing the interaction of both treatment modalities. Combination of HESW and ionising radiation turned out to act additively or slightly supra-additively on both biologic models.

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