Effects of high-energy shock waves combined with biological response modifiers or Adriamycin on a human kidney cancer xenograft

✍ Scribed by Oosterhof, G. O. N. ;Smiths, G. A. H. J. ;deRuyter, J. E. ;Schalken, J. A. ;Debruyne, F. M. J.

• Publisher: Springer
• Year: 1990
• Tongue: English
• Weight: 792 KB
• Volume: 18
• Category: Article
• ISSN: 0300-5623
• DOI: 10.1007/bf00297376

✦ Synopsis

We have studied the effect of high-energy shock waves (HESW) alone or in combination with biological response modifiers (BRMs) or Adriamycin on the growth of the NU-1 human kidney cancer xenograft. When HESW are administered repeatedly (four sessions of 800 shock waves on days 0, 2, 4 and 6) a prolonged delay in tumor growth was found compared with that following a single administration. This effect was temporary, and several days after stopping the HESW administration the tumor regained its original growth potential (same doubling time). Tumor growth was suppressed for a longer period by the combination of 4 sessions of HESW and a single administration of Adriamycin, 5 mg/kg. Combination of HESW treatment with interferon alpha (5.0 ng/g body weight, three times/week) and tumor necrosis factor alpha (500 ng/g body weight, 5 days/week) s.c. around the tumor resulted in a complete cessation of tumor growth. While Adriamycin had an additive effect on HESW treatment, the combination with BRMs was highly synergistic.