The combined effect of a non selective and a selective cyclooxygenase-2 inhibitor and 5- fluorouracil treatment on HCA-7 human colorectal carcinoma cell line
✍ Scribed by A. Réti; B. Budai; V. Komlósi; V. Adleff; G. Barna; A. Jeney; J. Kralovánszky
- Book ID
- 119598519
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 85 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1359-6349
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract ## Background. The protooncogenes Ets‐1 and Ets‐2 are involved in carcinogenesis of different tumors. Nimesulide, a selective cyclooxygenase‐2 (COX‐2) inhibitor, has antiproliferative effects on tumor cells. The question arises whether nimesulide influences Ets‐1 and Ets‐2 synthesis in
Gamma-Interferon (IFN-y) and the antimetabolites 5fluorouracil(5-FU) and 5-fluoro-2'-deoxyuridine (FUdR) were investigated as individual agents and in combination for their in vitro antiproliferative capacity and for their effect on the expression of HLA class-I antigen, carcinoembryonic antigen (CE