Enzymatic resolution of 2-acyl-3-hydroxy
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Kimihiro Mizuno; Shohei Sakuda; Takuya Nihira; Yasuhiro Yamada
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Article
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1994
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Elsevier Science
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French
β 560 KB
Racemic 2-acyl-3-hydroxymethykl-butanolides were resolved through a @se-catalyzed acylation with acetic anhydride. Optically active forms of 2-butyryl-3-hydroxymethyl-4-butanolide 14 obtained were used to prepare enantiomers of IM-2 10, the autoregulator from Srrepfomyces sp. FRI-5. The absolute con