ChemInform Abstract: Enzymatic Resolution of 2-Acyl-3-hydroxymethyl-4-butanolide and Preparation of Optically Active IM-2, the Autoregulator from Streptomyces sp. FRI-5.

Enzymatic resolution of 2-acyl-3-hydroxy

Enzymatic resolution of 2-acyl-3-hydroxymethyl-4-butanolide and preparation of optically active IM-2, the autoregulator from Streptomyces sp. FRI-5

✍ Kimihiro Mizuno; Shohei Sakuda; Takuya Nihira; Yasuhiro Yamada 📂 Article 📅 1994 🏛 Elsevier Science 🌐 French ⚖ 560 KB

Racemic 2-acyl-3-hydroxymethykl-butanolides were resolved through a @se-catalyzed acylation with acetic anhydride. Optically active forms of 2-butyryl-3-hydroxymethyl-4-butanolide 14 obtained were used to prepare enantiomers of IM-2 10, the autoregulator from Srrepfomyces sp. FRI-5. The absolute con