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✦   LIBER   ✦

The clinical course of lung carcinoma in patients with chronic lymphocytic leukemia

✍ Scribed by Kalpaj Parekh; Valerie Rusch; Mark Kris

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
70 KB
Volume
86
Category
Article
ISSN
0008-543X

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✦ Synopsis

BACKGROUND.

Although patients with chronic lymphocytic leukemia (CLL) have an increased risk of developing second primary malignancies, including lung carcinoma, there is virtually no information about their clinical outcomes. To evaluate this, the authors reviewed their 20-year institutional experience with CLL patients who also had lung carcinoma.

METHODS.

The records of patients with diagnoses of both CLL and lung carcinoma seen between January 1977 and July 1998 were reviewed. The data collected included patient demographics, the tumor histology and stage, the type of treatment for both CLL and lung carcinoma, the presence of a third malignancy, the disease status at last follow-up, and the first site of relapse. Survival was calculated by the Kaplan-Meier method.

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T h e in vitro peripheral lymphocyte response to phytohemagglutinin (PHA) was correlated with the clinical and immunologic status in 44 patients with chronic lymphocytic leukemia. T h e mean lymphocyte response was only slightly below the normal range a t day 3 of culture in patients in remission;