Studies of correlation of lymphocyte response to phytohemagglutinin with the clinical and immunologic status in chronic lymphocytic leukemia

✍ Scribed by Tin Han

• Publisher: John Wiley and Sons
• Year: 1973
• Tongue: English
• Weight: 427 KB
• Volume: 31
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(197302)31:2<280::aid-cncr2820310202>3.0.co;2-o

✦ Synopsis

T h e in vitro peripheral lymphocyte response to phytohemagglutinin (PHA)

was correlated with the clinical and immunologic status in 44 patients with chronic lymphocytic leukemia. T h e mean lymphocyte response was only slightly below the normal range a t day 3 of culture in patients in remission; but a majority of these patients showed delayed maximum responses. I n contrast, the PHA response was markedly depressed a n d delayed in patients with active disease. T h e lymphocyte response to PHA was well correlated with the duration of disease, the status of disease, the status of therapy, the degree of lymphocytosis, a n d the status of immunoglobulin level in patients with this disease.