The clastogenic effect of azathioprine on human chromosomesin vitro
✍ Scribed by J. Zyl; H. F. Wissmüller
- Publisher
- Springer
- Year
- 1974
- Tongue
- English
- Weight
- 761 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0340-6717
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In this study the clastogenic effect of pyrimethamine (Daraprim), a folic acid antagonist used for the treatment of toxoplasmosis and malaria on human chromosomes, was investigated. Pyrimethamine was added to in vitro lymphocyte cultures at six different concentrations: 0.05 (normal therapeutic dose
## Abstract Chromosome studies were performed on bone marrow aspirates from 15 patients treated with azathioprine. In most patients the immunosuppressive therapy produced structural changes of the chromosome complement. The structural chromosome aberrations disappeared after cessation of therapy. I