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The Chiral Diamine Mediated Asymmetric Baylis–Hillman Reaction

✍ Scribed by Yujiro Hayashi; Tomohiro Tamura; Mitsuru Shoji


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
117 KB
Volume
346
Category
Article
ISSN
1615-4150

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✦ Synopsis


Abstract

A chiral diamine, easily prepared from proline, is an effective, asymmetric organic catalyst for the Baylis–Hillman reaction of aldehydes and methyl vinyl ketone, affording adducts with enantioselectivities up to 75%.


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