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The chemistry of the leucomycins. II. Structure and stereochemistry of leucomycin A3.

✍ Scribed by Satoshi Ōmura; Haruo Ogura; Toju Hata

Publisher
Elsevier Science
Year
1967
Tongue
French
Weight
221 KB
Volume
8
Category
Article
ISSN
0040-4039

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✦ Synopsis

In the previous communication 1) , it was described that leucomycin A3 is a macrolide containing mycaminose and isovaleryl mycarose. In this paper we propose the full structure of leucomycin A3 (I) and also the stereochemistry of the mycarosidic linkages of spiramycin and magnamycin 2) in relation to leucomycin AT. Dehydroleucomycin A3 1) obtained from I by oxidation with MnOL is identical with magnamycin B 3) as compared by IR, UV and NMR spectra, and behavior on thin layer chromatography. From these

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