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The chemistry of cephamycins. II. Novel synthesis of 3-halomethyl cephalosporins

โœ Scribed by Sandor Karady; Theresa Y. Cheng; Seemon H. Pines; Meyer Sletzinger


Book ID
104243427
Publisher
Elsevier Science
Year
1974
Tongue
French
Weight
181 KB
Volume
15
Category
Article
ISSN
0040-4039

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Novel 3-hydroxy, 3-methyl cephalosporins
โœ Gerald E. Gutowski; Bennie J. Foster; Cecelia J. Daniels ๐Ÿ“‚ Article ๐Ÿ“… 1971 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 190 KB

The acid catalyzed ring expansion (1) of penicillin sulfoxide esters, 1, to deacetoxy cephalosporins, 2, has assumed added importance due to the demonstrated oral effectiveness of the broad-spectrum antibiotic, cephalexin (2). We now wish to report additional studies that further aid in elucidating