The chemical synthesis of phosphorothioate and phosphorodithioate analogues of lysophosphatidic acid (LPA) and cyclic phosphatidic acid (CPA)
✍ Scribed by Rytczak, Przemysław; Koziołkiewicz, Maria; Okruszek, Andrzej
- Book ID
- 120290088
- Publisher
- Royal Society of Chemistry
- Year
- 2010
- Tongue
- English
- Weight
- 602 KB
- Volume
- 34
- Category
- Article
- ISSN
- 1144-0546
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📜 SIMILAR VOLUMES
Cyclic phosphatidic acid (CPA) is a naturally occurring analog of lysophosphatidic acid (LPA) in which the sn-2 hydroxy group forms a five-membered ring with the sn-3 phosphate. Here, we describe the synthesis of R-3-CCPA and S-3-CCPA along with their pharmacological properties as inhibitors of lyso
A series of phosphonic acid analogues of phosphatidic acid and phosphatidyl choline have been synthesized in which an olefinic linkage has been incorporated into the backbone portion of the molecule. These analogues bear a structural rigidity not available with simple isosteric or non-isosteric phos