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Phosphonolipids. The synthesis of chiral vinylic phosphonolipid analogues of phosphatidic acid and phosphatidyl choline

✍ Scribed by Patricia Waters Schwartz; Burton E. Tropp; Robert Engel

Publisher: Elsevier Science
Year: 1988
Tongue: English
Weight: 532 KB
Volume: 49
Category: Article
ISSN: 0009-3084
DOI: 10.1016/0009-3084(88)90058-8

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✦ Synopsis

A series of phosphonic acid analogues of phosphatidic acid and phosphatidyl choline have been synthesized in which an olefinic linkage has been incorporated into the backbone portion of the molecule. These analogues bear a structural rigidity not available with simple isosteric or non-isosteric phosphonic acid analogues of the phospholipids, and incorporate a region of high electron density near the phosphonyl center.

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