The Chemical Constituents from the Callus Culture of Trewia nudiflora

✍ Scribed by Zhi-Zhi Du; Pei-Ji Zhao; Hong-Ping He; Na Zhu; Xiao-Jiang Hao; Yue-Mao Shen

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: German
• Weight: 77 KB
• Volume: 88
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200590178

✦ Synopsis

Abstract

Five ent‐atisane diterpenoids, including three new ones, i.e., (16__α__)‐17‐hydroxy‐ent‐atisan‐19‐oic acid methyl ester (1), (16__α__)‐17‐dihydroxy‐ent‐atisan‐19‐oic acid methyl ester (2), (16__α__)‐ent‐atisan‐16,17,19‐triol (3), and two known compounds, i.e., 17‐hydroxy‐ent‐atisan‐19‐oic acid (4), (16__α__)‐16,17‐dihydroxy‐ent‐atisan‐19‐al (5), together with one known diterpene glycoside, i.e., sumogaside, two known triterpenes, i.e., germanicone and (3__β__)‐β‐amyrin, three known phenolic compounds, i.e., (+)‐gallocatechin, (+)‐catechin, and gallic acid, and two known sterols, i.e., β‐sitosterol and daucosterol, were isolated from the callus cultures of Trewia nudiflora. Their structures were elucidated by spectroscopic analysis including 1D‐ and 2D‐NMR experiments. No maytansinoids were isolated or detected by LC‐ESI‐MS in the extracts of the calli, which suggests that the callus cultures can not produce maytansinoids under these conditions.