Three New ent-Trachylobane Diterpenoids from Co-cultures of the Calli of Trewia nudiflora and Fusarium sp. WXE
✍ Scribed by Xin Wu; Chun-Hua Lu; Yue-Mao Shen
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- German
- Weight
- 170 KB
- Volume
- 92
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Five diterpenoids, including three new ent-trachylobane diterpenoids, i.e., (3a)-3-hydroxy-enttrachylobane-17,19-dioic acid 19-methyl ester (1), ent-trachylobane-17,19-dioic acid 19-methyl ester (2), ent-trachylobane-17,19-dioic acid (3), and two known atisane-type ones, i.e., (16a)-16,17-dihydroxy-entatisan-19-oic acid methyl ester (4), and 17-hydroxy-ent-atisan-19-oic acid methyl ester (5), were isolated from the co-culture extract of the calli of Trewia nudiflora and its endophytic fungus Fusarium sp. WXE. Their structures were elucidated by spectroscopic analyses, including 1D-and 2D-NMR experiments, and HR-Q-TOF mass spectrometry. The antitumor and antibacterial properties of the new compounds were evaluated.