The FRA16D, at 16q23, spans the WWOX gene and is one of the most highly expressed common fragile sites observed when DNA replication is perturbed by aphidicolin. Several lines of evidence suggest that fragile sites are regions of DNA that are unusually sensitive to interference during replication. W
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The Characterization of the Common Fragile Site FRA16D and Its Involvement in Multiple Myeloma Translocations
โ Scribed by Kurt A Krummel; Lewis R Roberts; Masako Kawakami; Thomas W Glover; David I Smith
- Book ID
- 115615236
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 311 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0888-7543
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Recently, several common fragile sites (CFSs) have been cloned and characterized, including the two most frequently observed in the human population, FRA3B and FRA16D. In addition to their high frequency of breakage, FRA3B and FRA16D colocalize with genes crossing large regions of breakage. At FRA3B
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