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The characterization of plasma membrane Ca2+-ATPase in rich sphingomyelin–cholesterol domains

✍ Scribed by Yuhong Pang; Hua Zhu; Ping Wu; Jianwen Chen

Book ID
116465496
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
174 KB
Volume
579
Category
Article
ISSN
0014-5793

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The purified Ca2+/Mg2+ ATPase from rat heart plasma membrane was activated by Ca2+ and Mg2+ with Ka values of 1.47 mM and 2.51 mM, respectively; other divalent cations also activated the enzyme but to a lesser extent. Divalent cations like Cu2+, Zn2+, Ni2+, Cd2+ were potent inhibitors of the enzyme