A Biginelli-like three-component condensation using 3-amino-1,2,4-triazole as urea component resulted in an unexpected alternative direction of the tetrahydropyrimidine ring formation.
The chameleon-like behaviour of 3-amino-1,2,4-triazole in the Biginelli reaction: unexpected formation of a novel spiroheterocyclic system
✍ Scribed by Jan Světlík; Viktor Kettmann
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- French
- Weight
- 379 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0040-4039
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## Abstract magnified image The three‐component condensation of 3‐amino‐5‐alkylthio‐1,2,4‐triazoles with aromatic aldehydes and β‐ketoester was studied to develop a regioselective Biginelli‐like reaction. The results indicated that the reaction solvent and the properties of the β‐ketoester compone
## Abstract For Abstract see ChemInform Abstract in Full Text.
It is known [1, 2] that the reactions of binucleophiles with ketones containing the activated methyl or methylene group, or with the products of the self-condensation of these ketones, may lead to one and the same substance. We established that the boiling of the solutions of the 3-amino-l,2,4-triaz