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The cell cycle phases of DNA damage and repair initiated by topoisomerase II-targeting chemotherapeutic drugs

โœ Scribed by Alan J. Potter; Peter S. Rabinovitch


Book ID
113808560
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
568 KB
Volume
572
Category
Article
ISSN
0027-5107

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## Background Bisdioxopiperazine anti-cancer agents are inhibitors of eukaryotic DNA topoisomerase II, sequestering this protein as a non-covalent protein clamp on DNA. It has been suggested that such complexes on DNA represents a novel form of DNA damage to cells. In this report, we characterise t