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The CD95(APO-1/Fas) DISC and beyond

✍ Scribed by Peter, M E; Krammer, P H

Book ID
110016516
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
326 KB
Volume
10
Category
Article
ISSN
1350-9047

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This review covers recent advances of CD95 signaling. It focuses on CD95-interacting molecules, formation of the death inducing signaling complex and the role of caspases, particularly caspase-8, and their death substrates. We also discuss the relevance of mitochondria in the CDg5-mediated apoptotic