✦ LIBER ✦

Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis

✍ Scribed by Marcus E Peter; Peter H Krammer

Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 725 KB
Volume: 10
Category: Article
ISSN: 0952-7915
DOI: 10.1016/s0952-7915(98)80222-7

No coin nor oath required. For personal study only.

✦ Synopsis

This review covers recent advances of CD95 signaling. It focuses on CD95-interacting molecules, formation of the death inducing signaling complex and the role of caspases, particularly caspase-8, and their death substrates. We also discuss the relevance of mitochondria in the CDg5-mediated apoptotic process and how viral proteins interfere with crucial steps of this signaling pathway.

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