## Abstract For Abstract see ChemInform Abstract in Full Text.
The Catalytic Asymmetric Mannich-Type Reactions in Aqueous Media
✍ Scribed by Kobayashi, Shū; Hamada, Tomoaki; Manabe, Kei
- Book ID
- 126282986
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 37 KB
- Volume
- 124
- Category
- Article
- ISSN
- 0002-7863
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📜 SIMILAR VOLUMES
## Abstract Catalytic asymmetric Mannich‐type reactions of an α‐hydrazono ester with silicon enolates in aqueous media have been developed by using ZnF~2~ and chiral diamines as catalysts. In these reactions, both Zn^2+^ and a fluoride anion were necessary to achieve high yields and enantioselectiv
The first direct organocatalytic asymmetric Mannich-type reactions in aqueous media are demonstrated herein. L-Proline-catalyzed reactions in aqueous media to provide b-formyl substituted a-amino acid derivatives with excellent diastereoselectivities (dr up to 19:1, syn/anti ) and high enantioselect